CHLOROQUINE AS POSSIBLE TREATMENT FOR COVID-19

Mar 13, 2020 by

3.12.20 – FROM DONNA GARNER

CHLOROQUINE AS A POSSIBLE TREATMENT FOR COVID-19

Please watch this MedCram Update 24 on YouTube dated 3.10.20. This is excellent, current, and reliable medical information on COVID-19 and was recommended to me by an experienced medical doctor. Further on down the page, I have posted some concerns tied to Chloroquine disphosphate:

LINK TO YOUTUBE VIDEO:  https://youtu.be/U7F1cnWup9M

My summary of this information:

This is really encouraging news about a possible medical breakthrough for those who contract COVID-19. Obviously controlled, blind, randomized trials need to be done to make sure; and I have highlighted in red (below) the possible side effects. 

Here is what I got out of this YouTube: Chloroquine disphosphate (already used widely for malaria cases) seems to open the gate to allow the zinc to help alleviate COVID-19.  “Increased intracellular levels of zinc prevent the viral RNA from hijacking the cell’s machinery. It blocks the replication of the virus within the cell.”  South Korea through its trial studies (used on the elderly) recommends 7 to 10 days (1 pill per day – 500 mg) of Chloroquine. Their study published in the medical research is dated 2.13.20. Chloroquine in the U. S. requires a doctor’s prescription.

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3.6.20 – Science Translational Medicine:   https://blogs.sciencemag.org/pipeline/archives/2020/03/06/covid-19-small-molecule-therapies-reviewed

One of the screens of known drugs in China that also flagged remdesivir noted that the old antimalarial drug chloroquine seemed to be effective in vitro. It had been reported some years back as a possible antiviral, working through more than one mechanism, probably both at viral entry and intracellularly thereafter. That part shouldn’t be surprising – chloroquine’s actual mode(s) of action against malaria parasites are still not completely worked out, either, and some of what people thought they knew about it has turned out to be wrong. There are several trials underway with it at Chinese facilities, some in combination with other agents like remdesivir.

Chloroquine has of course been taken for many decades as an antimalarial, but it has a number of liabilities, including seizures, hearing damage, retinopathy and sudden effects on blood glucose. So it’s going to be important to establish just how effective it is and what doses will be needed. Just as with vaccine candidates, it’s possible to do more harm with a rushed treatment than the disease is doing itself.

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PRIME PubMed 2020:  https://www.unboundmedicine.com/medline/citation/32074550/full_citation

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BIO SCIENCE TRENDS 2020:  https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_2020.01047/_article

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