LANCET ISSUES EXPRESSION OF CONCERN OVER ITS HIT PIECE ON HYDROXYCLOROQUINE

Jun 3, 2020 by

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“Lancet Issues Expression of Concern over Its Hit Piece on Hydroxychloroquine”

By Donna Garner

6.3.20

“Expression of concern: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis”  — The Lancet Editors – Published: June 03,2020

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31290-3/fulltext

Important scientific questions have been raised about data reported in the paper by Mandeep Mehra et al—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

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—published in The Lancet on May 22, 2020.

Although an independent audit of the provenance and validity of the data has been commissioned by the authors not affiliated with Surgisphere and is ongoing, with results expected very shortly,we are issuing an Expression of Concern to alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.

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*To read the background for Lancet’s Expression of Concern:

“Lancet Authors:  Ignore 9 of 10 Mistakes Made in Hydroxychloroquine Study”

By Donna Garner

6.1.20

[COMMENTS FROM DONNA GARNER: Please notice that the authors of the 5.22.20 Lancet study on hydroxychloroquine only agreed to correct one of their mistakes but refused to acknowledge the other nine mistakes mentioned in the letter sent to them by 100 scientists and medical professionals who are from all over the world. 

Besides this 5.31.20 20 article (below) from Epoch Times, the following article published on 5.28.20 by Dr. Susan Berry in Breitbart lays out the very questionable data and conclusions of the Lancet study: “Study Prompting W.H.O. to Halt Hydroxychloroquine Trials Questioned” – by Dr. Susan Berry – Breitbarthttps://www.educationviews.org/lancet-study-prompting-w-h-o-to-halt-hydroxychloroquine-trials-questioned/  ]

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5.31.20 – Epoch times

“Hydroxychloroquine Study Corrected After More Than 100 Scientists Question Findings”

By Katabella Roberts

https://www.theepochtimes.com/hydroxychloroquine-study-corrected-after-more-than-100-scientists-question-findings_3371001.html?__sta=vhg.uosvpxBVvofbd%7CBJH&__stm_medium=email&__stm_source=smartech

Excerpts from this article:

Medical journal The Lancet on May 29 issued a correction to a recent study which found that antimalarial drugs Hydroxychloroquine and chloroquine were linked with an increased risk of mortality in hospitals, and an increased frequency of irregular heart rhythms.

The study, titled, “Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis,” and published on May 22, included records of 96,032 patients from 671 hospitals in six continents. The patients were hospitalized between Dec. 20, 2019, and April 14, 2020.

Patients receiving the anti-malarials were put in four different groups: chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide. Patients who received none of the treatments formed a control group. Researchers found the 14,888 patients in the treatment group suffered higher mortality when compared to the control group of over 80,000.

…The study led the World Health Organization to temporarily suspend the trial of hydroxychloroquine on COVID-19 patients, and to the UK regulatory body, MHRA, requesting the temporary pause of recruitment into all hydroxychloroquine trials in the UK. France also changed its national recommendation of the drug in COVID-19 treatments and halted all trials.

However, more than a hundred scientists and medical professionals raised questions about integrity of data analyzed in the study and subsequently wrote an open letter to its authors and the editor of The Lancet, listing 10 major concerns.

These included the fact that there was “no ethics review,” and “unusually small reported variances in baseline variables, interventions and outcomes,” as well as “no mention of the countries or hospitals that contributed to the data source and no acknowledgments to their contributions.” A request to the authors for information on the contributing centers was denied, the letter said.

Among the scientists other concerns were that the average daily doses of hydroxychloroquine were higher than the FDA-recommended amounts and that data reportedly from Australian patients did not seem to match data from the Australian government.

“Too many cases for just five hospitals, more in hospital deaths than had occurred in the entire country during the study period,” they wrote, noting that Surgisphere, a healthcare data analytics company, has since stated this was an error of classification of one hospital from Asia. “This indicates the need for further error checking throughout the data base,” they wrote.

The scientists also said the authors “have not adhered to standard practices in the machine learning and statistics community. They have not released their code or data.”

“Data from Africa indicate that nearly 25% of all COVID-19 cases and 40% of all deaths in the continent occurred in Surgisphere-associated hospitals which had sophisticated electronic patient data recording, and patient monitoring able to detect and record ‘nonsustained [at least 6 secs] or sustained ventricular tachycardia or ventricular fibrillation.’ Both the numbers of cases and deaths, and the detailed data collection, seem unlikely.”

The Lancet’s study was informed by data from Surgisphere of which Sapan Desai, the president and Chief Executive Officer, is listed as one of the four authors.

“We discovered that a hospital that joined the Surgisphere registry on April 1, 2020 (in between our quarterly audit periods) self-designated as belonging to the Australasia continental designation. In reviewing the data from each of the hospitals in the registry, we noted that this hospital should have more appropriately been assigned to the Asian continental designation,” Surgisphere said in a statement.

“This hospital was properly reclassified in our database. The findings of the paper are unaffected by this update,” the company said.

In the correction issued on Friday, The Lancet also mentioned the same hospital.

“The appendix has also been corrected. An incorrect appendix table S3 was included, originally derived from a propensity score matched and weighted table developed during a preliminary analysis. The unadjusted raw summary data are now included.”

The Lancet added that there “have been no changes to the findings of the paper,” and that the corrections have been made to the online version and will also be made to the printed version.

In response to the correction issued on May 29, James Watson, a Thailand-based statistician with the University of Oxford’s Centre for Tropical Medicine and Global Health, who led the drafting of the letter, told BuzzFeed News that the authors of the study had failed to address the other nine points referred to in the letter.

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    Thank you, Donna, for sharing this. I look forward to a follow up with the WHOLE STORY. You are, as always, “on the ball” and so many times you are the first person to get the truth out on so very many issues. It’s critical that patients get the best treatment and that physicians are presented with the facts. I can’t believe there is so much baloney in today’s media that it’s difficult to know what’s true, but it’s essential that we find out before more lives are lost. Thanks also to Education Views which has been one of my best news sources since my husband gave me my first computer for my birthday in 1996.

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